|The following information (Health Effects, Handling/Disposal, and Ingredients) is taken from the product label and/or the Material Safety Data Sheet (MSDS) prepared by the manufacturer. The National Library of Medicine does not test products nor does it evaluate information from the product label or the MSDS. (What is an MSDS?)
(Complete MSDS for this product)
|MSDS: WARNING MESSAGES:|
(1) Reports have associated repeated and prolonged occupational overexposure to solvents with permanent brain and nervous system damage. Intentional misuse by deliberately concentrating and inhaling the contents may be harmful or fatal. Chronic exposure may cause damage to the central nervous system, respiratory system, lung, eye, skin, liver, gastrointestinal tract, spleen, kidneys, and blood.
*WARNING! If you scrape, sand, or remove old paint, you may release
lead dust. LEAD IS TOXIC. EXPOSURE TO LEAD DUST CAN CAUSE
SERIOUS ILLNESS, SUCH AS BRAIN DAMAGE, ESPECIALLY IN
CHILDREN. PREGNANT WOMEN SHOULD ALSO AVOID EXPOSURE.
Wear a NIOSH-approved respirator to control lead exposure. Clean up
carefully with a HEPA vacuum and wet mop. Before you start, find out
how to protect yourself and your family by contacting the national Lead
Information Hotline at 1-800-424-LEAD or log on to www.epa.gov/lead.
|From MSDS |
EFFECTS OF OVEREXPOSURE:
Odor Threshold- There is no available information on the polymeric
isocyanate. The odor threshold for Toluene
2,4-diisocyanate is 0.17 ppm. TDI is considered
to have a poor warning properties, that is if you
can smell it, then it is above the recommended
occupational standards for the compound.
Irritation Threshold- The irritation threshold for this product
has not been clearly established because those
persons sensitized to TDI may show signs and
symptoms of irritation at levels far below those
that are not sensitized.
Acute: Exposure may cause mucous membrane and respiratory tract
irritation, tightness of chest, headache, shortness of
breath, and a dry cough. Inhalation may cause headaches,
drowsiness, unconsciousness, anesthesia and asthma-like
symptoms to occur. These symptoms may include coughing,
wheezing, and shortness of breath. A hypersensitive
pneumonitis may also occur if the person is sensitized.
This syndrome is characterized by fever, nonproductive
cough, wheezing, chills, and shortness of breath. The
effects of acute exposure may be delayed in onset up to
Chronic: Repeated exposure may cause an allergic sensitization
of the respiratory tract. This is characterized by an
asthma-like response upon re-exposure to the chemical.
The symptoms may include coughing, wheezing, shortness
of breath and chest tightness. Repeated overexposure
to isocyanates and high one-time accidental exposures
to isocyanates have been associated with a gradual
decrease in lung volume (lung damage).
Acute: If not properly removed, liquid spills of TDI on the skin
may cause irritation, redness, swelling, blistering or
Chronic: Repeated contact may cause irritation of the skin and
an allergic skin reaction consisting of a hive-like rash
on locations not even directly contacted by the liquid.
Animal studies indicate that dermal exposure to TDI may
induce an allergic sensitization of the respiratory tract
as well. This is characterized by an asthma-like
response which may include coughing, wheezing, shortness
of breath, chest tightness, and may be fatal.
Eye- The effects of liquid directly contacting the eye can be
significant. This may result in severe irritation and possible
damage to the cornea and impairment of vision. The effects of
high vapor concentrations may vary from slight irritation with
tearing and burning sensation to keratitis consisting of
inflammation of the cornea and impairment of vision.
Acute: Can result in irritation of the mouth, stomach tissue and
digestive tract. Gastroenteritis may result with any or
all of the following symptoms; nausea, vomiting diarrhea,
headache. Small amounts aspirated into the lungs during
ingestion or vomiting may cause mild to severe pulmonary
injury and possibly death.
Chronic: More pronounced gastroenteritis effects would probably
occur if this material was repeatedly ingested.
Target organ toxicity- Irritation to the skin, eyes, mucous
membrane, and respiratory tract.
Reproductive and developmental toxicity- TDI is not known or
reported to be a developmental or reproductive toxin.
MEDICAL CONDITIONS GENERALLY AGGRAVATED BY EXPOSURE:
Asthma, Chronic respiratory disease (e.g. Bronchitis, Emphysema)
Eye disease, Skin disorders and Allergies.
PRIMARY ROUTE(S) OF ENTRY: Inhalation, skin contact, skin absorption &
|From MSDS |
Refer to Acute Health
|From MSDS |
Carcinogenicity- TDI is reported to be carcinogenic by the
following agencies: IARC, NTP. These determinations have
been based on the following information. TDI isocyanate
has been shown to cause cancer in laboratory animals when
administered orally at high dose levels in corn oil. This
study was conducted under the auspices of the US National
Toxicology Program. It has been postulated that the
positive results (tumor formation) in this study may have
been caused by the hydrolysis of TDI to TDA, a known
carcinogen. The relevant route of industrial exposure to
this product is through inhalation. Other studies,
sponsored by the International Isocyanate Institute have
shown that TDI does not produce cancer when administered
to laboratory animals via inhalation. The dose levels in
the inhalation studies were significantly lower than those
of the studies in which TDI given orally in corn oil, and
TDI is not hydrolyzed to TDA when administered via the
inhalation route of exposure. The route of exposure and
level of dose used on the inhalation work reflect more
accurately the conditions of industrial exposure. Based on
the lack of carcinogenic response in animals from
inhalation of TDI, the manufacturer of the TDI judges that
the risk of cancer in humans from industrial use of this
substance is not significant.
Xylene contains ethylbenzene which has been classified as
a possible carcinogen to humans, Class 2B, by the
International Agency for Research of Cancer (IARC), based
on sufficient evidence in laboratory animals but
inadequate evidence for cancer in humans. Prolonged or
repeated overexposure to ethylbenzene may cause the
following: kidney effects, liver effects, lung effects,
thyroid effects, testicular effects, pituitary effects.
Mutagenicity- TDI has produced both positive and negative results in
the Ames Salmonella gene mutation assay. A positive
result may have been caused by hydrolysis of the TDI to
TDA, a know mutagen. Other in vitro test systems have
also reported positive results, also probably due to the
water-TDI interaction. In vivo (whole animal studies)
have reported negative results. A micronucleus assay to
measure chromosomal effects potential was performed in
conjunction with the two year rat inhalation study showed
negative results. An unscheduled DNA synthesis assay
conducted dosing the animals in vivo also showed TDI not
to be mutagenic under this system's conditions. The
significance of all these tests for human health is
unclear other then to conclude that TDI is a reactive
chemical and has some possible significant biological
|From MSDS |
EYES- Immediately flush with large amounts of water for at least 15
minutes, occasionally lifting the upper and lower eyelids. Call a
physician at once.
SKIN- Immediately flush with water for 15 minutes. Wash the
contaminated skin with soap and water. If irritation develops, call
a physician. If clothing comes in contact with the product, the
clothing should be laundered before reuse.
INGESTION- Immediately drink large quantities of water. DO NOT induce
vomiting. Call a physician at once. DO NOT give anything by mouth
if the person is unconscious or if having convulsions.
INHALATION- If person experiences nausea, headache or dizziness,
person should stop work immediately and move to fresh air until
these symptoms disappear. If breathing is difficult, administer
oxygen, keep the person warm and at rest. Call a physician. In the
event that an individual inhales enough product to lose
consciousness, person should be moved to fresh air at once and a
physician should be called immediately. If breathing has stopped,
artificial respiration should be given immediately. In all cases,
ensure adequate ventilation and provide respiratory protection
before the person returns to work.
|From MSDS |
Keep away from heat. Keep away from sparks, flames and other
sources of ignition. Store in a cool, dry place. Keep
container closed when not in use. Avoid contact with eyes,
skin and clothing. Avoid breathing vapor or mist. Use with
adequate ventilation. Ground and bond containers when
transferring material. Use explosion proof equipment. Follow
all MSDS/label precautions even after the container is emptied
because it may retain product residues. Wash thoroughly after
OTHER PRECAUTIONS: Avoid resealing containers that have been contaminated with water. The resulting reaction could cause a
pressure within the container which is great enough to
burst the container.
|From MSDS |
Waste must be disposed of in accordance
with federal, state and local environmental control
regulations. Incineration is the preferred method.
Empty containers must be handled with care due to
product residue. Decontaminate prior to disposal.
Ingredients from MSDS/Label
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