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Home Products Manufacturers Ingredients Health Effects
Product Information
Product Name: Prestone Concentrate Antifreeze-Coolant, AF2000-08/20/2018
Form: liquid
Product Category: Auto Products » cooling system » Antifreeze
Auto Products » antifreeze/coolant » Cooling System
Customer Service: 888-269-0750
Date Entered: 2018-09-05
Related Items: Products with similar usage in this database
Manufacturer: Prestone Products Corp.
Div., Honeywell International, Inc.
Address: 69 Eagle Road
City: Danbury
State: CT
Zip Code: 06810
Telephone Number: 847-482-2045
Fax Number: 203-830-7904
Toll Free Number: 800-269-0750
Date Info Verified: 2019-01-14
Related Items: Products by this manufacturer
The following information (Health Effects, Handling/Disposal, and Ingredients) is taken from the product label and/or the (Material) Safety Data Sheet, (M)SDS, prepared by the manufacturer. The National Library of Medicine does not test products nor does it evaluate information from the product label or the (M)SDS. (What is an (M)SDS?) (Complete (M)SDS for this product)
Health Effects
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Warnings: Hazard Statements

Warning. Harmful if swallowed. Suspected of damaging the unborn child. May cause damage to kidneys through prolonged or repeated exposure.

Precautionary Statements


Obtain special instructions before use. Do not handle until all safety precautions have been read and understood.


Do not breathe mist or vapors. Wash exposed skin thoroughly after handling. Do not eat, drink, or smoke when using this product. Wear protective gloves.


IF SWALLOWED: Call a POISON CENTER or physician if you feel unwell. Rinse mouth.

IF exposed or concerned: Get medical advice.


Store locked up.


Dispose of contents and container in accordance with local and national regulations.
Acute Health Effects: From SDS:

Hazards Identification

Emergency Overview

Warning. Harmful if swallowed. Suspected of damaging the unborn child. May cause damage to kidneys through prolonged or repeated exposure.

Potential Health Effects

Eye Contact: Liquid, vapors or mist may cause discomfort in the eye with persistent conjunctivitis, seen as slight excess redness or conjunctiva. Serious corneal injury is not anticipated.

Skin Contact: No evidence of adverse effects from available information.

Inhalation: May cause irritation of the nose and throat with headache, particularly from mists. High vapor concentrations caused, for example, by heating the material in an enclosed and poorly ventilated workplace, may produce nausea, vomiting, headache, dizziness and irregular eye movement.

Ingestion: May cause abdominal discomfort or pain, nausea, vomiting, dizziness, drowsiness, malaise, blurring of vision, irritability, back pain, decrease in urine output, kidney failure, and central nervous system effects, including irregular eye movements, convulsions and coma. Cardiac failure and pulmonary edema may develop. Severe kidney damage which may be fatal may follow the swallowing of ethylene glycol. A few reports have been published describing the development of weakness of the facial muscles, diminishing hearing, and difficulty with swallowing, during the late stages of severe poisoning.
Chronic Health Effects: From SDS:

Prolonged or repeated inhalation exposure may produce signs of central nervous system involvement, particularly dizziness and jerking eye movements. Prolonged or repeated skin contact may cause skin sensitization and an associated dermatitis in
Carcinogenicity: None of the components of these products is listed as a carcinogen or suspected carcinogen by IARC, NTP, ACGIH, or OSHA.
First Aid: Eye Contact: Immediately flush eyes with large amounts of water for 15 minutes. Get medical attention if irritation persists.

Skin Contact: Remove contaminated clothing. Immediately wash contacted area thoroughly with soap and water. If irritation persists, get medical attention.

Inhalation: Remove the victim to fresh air. If breathing has stopped administer artificial respiration. If breathing is difficult, have medical personnel administer oxygen. Get medical attention.

Ingestion: Seek immediate medical attention. Immediately call local poison control center or go to an emergency department. Never give anything by mouth to or induce vomiting in an unconscious or drowsy person.

Notes to Physician: The principal toxic effects of ethylene glycol, when swallowed, are kidney damage and metabolic acidosis. The combination of metabolic acidosis, an osmol gap and oxalate crystals in the urine is evidence of ethylene glycol poisoning. Pulmonary edema with hypoxemia has been described in a number of patients following poisoning with ethylene glycol. Respiratory support with mechanical ventilation may be required. There may be cranial nerve involvement in the late stages of toxicity from swallowed ethylene glycol. In particular, effects have been reported involving the seventh, eighth, and ninth cranial nerves, presenting with bilateral facial paralysis, diminished hearing and dysphagia. Ethanol is antidotal and its early administration may block the formation of nephrotoxic metabolites of ethylene glycol in the liver. The objective is to rapidly achieve and maintain a blood ethanol level of approximately 100 mg/dl by giving a loading dose of ethanol followed by a maintenance dose. Intravenous administration of ethanol is the preferred route. Ethanol blood levels should be checked frequently. Hemodialysis may be required. 4-Methyl pyrazole (Fomepizole), a potent inhibitor of alcohol dehydrogenase, has been used therapeutically to decrease the metabolic consequences of ethylene glycol poisoning. Fomepizole is easier to use clinically than ethanol, does not cause CNS depression or hypoglycemia and requires less monitoring than ethanol. Additional therapeutic modalities which may decrease the adverse consequences of ethylene glycol metabolism are the administration of both thiamine and pyridoxine. As there are complicated and serious overdoses, we recommend you consult with the toxicologists at your poison control center.
Health Rating: 1
Flammability Rating: 2
Reactivity Rating: 0
HMIS Rating Scale: 0 = Minimal; 1 = Slight; 2 = Moderate; 3 = Serious; 4 = Severe; 
N = No information provided by manufacturer; * = Chronic Health Hazard
MSDS Date: 2018-08-20
Handling: Harmful or Fatal if Swallowed. Do not drink antifreeze or solution. Avoid eye and prolonged or repeated skin contact. Avoid breathing vapors or mists. Wash exposed skin thoroughly with soap and water after use. Do not store in opened or unlabeled containers. Keep container away from open flames and excessive heat. Do not reuse empty containers unless properly cleaned. Empty containers retain product residue and may be dangerous. Do not cut, weld, drill, etc. containers, even empty. Sudden release of hot organic chemical vapors or mists from process equipment operating at elevated temperature and pressure, or sudden ingress of air into vacuum equipment, may result in ignitions without any obvious ignition sources. Published "autoignition" or "ignition" temperatures cannot be treated as safe operating temperatures in chemical processes without analysis of the actual process conditions. Use of this product in elevated temperature applications should be thoroughly evaluated to assure safe operating conditions. Store away from excessive heat and oxidizers.
Disposal: Dispose of product in accordance with all local, state/provincial and federal regulations.
Ingredients from (M)SDS/Label
ChemicalCAS No / Unique IDPercent
Ethylene glycol000107-21-180.0-100.0
Diethylene glycol000111-46-60-5.0
Hexanoic acid, 2-ethyl-, sodium salt (1:1)019766-89-31.0-5.0
Neodecanoic acid, sodium salt031548-27-31.0-5.0
(Complete (M)SDS for this product)
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